#11 – Molecular Basis for Why Plant and Paleo Diets Can Work

In this episode I do my best to provide an objective, science-based mechanism for how plant-based and paleo-type diets can be effective in reversing insulin resistance.  I cover the following: Molecular overview of insulin resistance Case descriptions of how plant-based and paleo-type diets…


#10 – The Liver’s Key Role in Metabolism and Insulin Resistance

It's time to introduce the liver into our metabolic framework and understand how it interacts with fat and muscle. We'll discuss: The metabolic triad of glucose, fat and muscle How the liver regulates glucose with extraordinary precision Understanding metabolism when fed, fasted, and in…


#9 – Fat Metabolism: How We Store, Move, and Burn Body Fat

This episode introduces fat metabolism through signature storytelling that involves ships, TSA agents, and a visit to a pub. We'll cover the following: Overlaps in fat and glucose metabolism The essence of fat mobilization and storage Key hormones for fat storage and burning Deeper…


#8 – Intro to Mitochondria and Energy Production

In prior episodes we discussed how glucose gets into cells from the bloodstream, but now it's time to dig deeper and understand how glucose and nutrients actually get into the mitochondria to produce energy.  Optimal mitochondrial function is essential for energy, weight control, and disease…


#7 – Have We Taken Fasting Too Far?

Fasting continues to be one of the top health and nutrition trends in the world.  Why wouldn't it be?  Weight loss, disease prevention and reversal, longevity benefits, and the list goes on.  As someone who has practiced fasting and prescribes it in the clinic, there is a dark side to fasting…


#6 – Molecular Root Cause for Insulin Resistance

We laid the groundwork for understanding the root cause of insulin resistance in prior episodes, and now we have reached a major climax in this saga where we discuss one of the molecular root causes for this condition.  There will be some James Bond references and an explanation of insulin…


#5 – Insulin Lock and Key Model of Metabolism

This episode will explain the important interaction between insulin, insulin receptor, and a key protein called IRS (insulin receptor substrate).  I'll use a simple lock and key model to simplify how these molecules interact and serve as an important doorway to metabolism.  Understanding the…


#4 – Rumination as a Gateway to Stress, Depression, and Anxiety

Find out why I call rumination pre-depression/pre-anxiety.  Identifying and solving for rumination can have a significant impact on reducing much of the suffering we experience on a daily basis.  In this episode I describe the science of rumination, common rumination movies that play inside our…


#2 – Deep Dive Into Glut Subtypes and Exercise

Glucose transporters (aka Glut) are a key protein that shuttles glucose into cells.  Understanding Glut helps you understand how your body transports and utilizes sugar, and how you can impact your glucose metabolism through lifestyle changes like exercise.  We'll use some clever mnemonics to…


#1 – Using Mangos to Explain Insulin and Glut4

This is the first of a series of episodes that digs deep into insulin's actions and uses what I call the "mango cell model" so you understand the key components of cell structure.  I'm also going to introduce a key glucose transporter called GLUT and end with my opinion about mangos and fruits…


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