#32 – New Directions

I'm feeling an urge to shift my content in a new direction. I'm not giving up on discussing metabolism since that's a topic that is still very close to my heart, but at the age of 52 and after digging deep into insulin resistance for well over a decade, I'm sensing a different pull. In this…


#29 – Acetyl CoA, Citrate, and the Metabolic Merry-Go-Round

I've selected 2 key metabolic ingredients, Acetyl CoA and Citrate, to explain nutrition metabolism in further detail. I've also selected a different storyline, the mitochondrial amusement park and the Kreb's merry-go-round, to help you visualize some of the most fundamental steps of metabolism.…


#25 – The Critical Pentose Phosphate Pathway and Erythritol

The pentose phosphate pathway, which I refer to as P3, is one of my favorite metabolic pathways and one that gets far less attention than glycolysis, gluconeogenesis, and Krebs, yet plays such a key role in our body. In this episode we go over the following: Brief refresher on glycolysis and…


Is Erythritol a Safe Sweetener?

Background The recent headlines about erythritol and its possible association with cardiovascular disease has led to a heavy stream of questions flooding my inbox. As always, there's so much more to this story than the headlines suggest. I'd like to use this study as another opportunity to…


#18 – Multiethnic Metabolism and Heart Disease Risk

There are significant ethnicity-specific differences in metabolism and heart disease risk that are not often discussed. In this episode we cover: A brief overview of insulin resistance (IR) and the renin angiotensin system (aka RAS) How IR and RAS present in major ethnic groups like African…


#17 – Blood Pressure, Body Fat, and Sodium

I'm going to explain the interaction between blood pressure, body fat, and sodium by explaining the all important RAAS (renin-angiotensin-aldosterone system). Understanding this system can help you optimize blood pressure, heart, and overall vascular health. We'll discuss the following:…


#11 – Molecular Basis for Why Plant and Paleo Diets Can Work

In this episode I do my best to provide an objective, science-based mechanism for how plant-based and paleo-type diets can be effective in reversing insulin resistance.  I cover the following: Molecular overview of insulin resistance Case descriptions of how plant-based and paleo-type diets…


#9 – Fat Metabolism: How We Store, Move, and Burn Body Fat

This episode introduces fat metabolism through signature storytelling that involves ships, TSA agents, and a visit to a pub. We'll cover the following: Overlaps in fat and glucose metabolism The essence of fat mobilization and storage Key hormones for fat storage and burning Deeper…


#8 – Intro to Mitochondria and Energy Production

In prior episodes we discussed how glucose gets into cells from the bloodstream, but now it's time to dig deeper and understand how glucose and nutrients actually get into the mitochondria to produce energy.  Optimal mitochondrial function is essential for energy, weight control, and disease…


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